Assessment of the severity of knee osteoarthritis based on the global fat fraction histogram of the infrapatellar fat pad
10.3969/j.issn.1002-1671.2025.11.017
- VernacularTitle:基于髌下脂肪垫全域脂肪分数直方图评估膝骨关节炎严重程度的研究
- Author:
Baogen ZHAO
1
;
Yujin ZHANG
1
;
Xin CHEN
1
;
Xiaoying WANG
1
;
Gang JI
1
;
Yong WANG
1
;
Li ZHANG
1
Author Information
1. 河北医科大学第一医院放射与核医学科,河北 石家庄 050011
- Publication Type:Journal Article
- Keywords:
histogram;
osteoarthritis;
mDIXON-Quant;
infrapatellar fat pad;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2025;41(11):1838-1841,1856
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between quantitative parameters of the histogram of global fat fraction(FF)in the infrapatellar fat pad(IPFP)and the severity of knee osteoarthritis(KOA).Methods A total of 120 patients were prospectively selected and divided into the non-KOA group(KL grade 0-1),the mild KOA group(KL grade 2),and the severe KOA group(KL grade 3-4)based on the Kellgren-Lawrence(KL)classification criteria of knee X-rays.The FF maps of the IPFP were obtained based on the mDIXON-Quant technique.The region of interest(ROI)was delineated using 3D Slicer software,and global histogram analysis was performed to obtain quantitative parameters,including mean,median,10th percentile(10th),90th percentile(90th),skewness,kurtosis,and entropy.Pearson or Spearman correlation analysis was used to evaluate the correlation between each quanti-tative parameter and the severity of KOA.The diagnostic efficacy was analyzed using the receiver operating characteristic(ROC)curves.Results As the progression of KL classification,the mean,median,percentiles,and kurtosis of the global FF histogram quantitative parameters in the IPFP decreased,while skewness and entropy increased,with statistically significant among the three groups(P＜0.001).The mean,median,10th,90th,and kurtosis showed negative correlations with the KL classification(r=-0.563,-0.448,-0.614,-0.294,-0.450),while skewness and entropy showed positive correlations with the KL classification(r=0.385,0.637),all of which were statistically significant(P＜0.05).The area under the curve(AUC)for diagnosing KOA were 0.799,0.725,0.828,0.636,0.741,0.688,and 0.830,respectively.The sensitivity of the 10th and entropy were 74.4％and 77.9％,respectively,and the specificity were 85.3％and 88.2％,respectively.Conclusion The quantitative parameters of the histogram of global FF in the IPFP are correlated with the severity of KOA and can reflect the pathophysiological changes in the IPFP.They can serve as objective indicators for diagnosing KOA and assessing its severity.
