Mechanism of alpha-synuclein in mitochondrial damage induced by Parkinson's disease
- VernacularTitle:α-突触核蛋白在帕金森疾病中诱导线粒体损伤的机制
- Author:
Jingying WANG
1
;
Binbin REN
;
Suna MA
;
Yueyue YANG
;
Song WU
;
Mengya GUAN
Author Information
- Publication Type:Journal Article
- Keywords: Parkinson's disease; α-synuclein; mitochondria; oxidative stress; calcium; mitochondrial dynamics; mitochondrial autophagy; protein introduction mechanism
- From: Chinese Journal of Tissue Engineering Research 2025;29(17):3668-3674
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Currently,the pathogenesis of Parkinson's disease is not clear.Relevant studies have shown that α-synuclein and mitochondria are closely related to the pathogenesis of Parkinson's disease.It mainly involves oxidative stress,mitochondrial complex damage,calcium homeostasis,mitochondrial dynamics and mitochondrial quality control.OBJECTIVE:To review the association between α-synuclein and mitochondrial damage in Parkinson's disease.METHODS:The first author searched more than 50 documents from CNKI and WanFang databases from 2010 to 2024 using the keywords of"Parkinson's disease,mitochondrial damage and mechanism,α-synuclein"in Chinese as well as more than 750 documents from PubMed between 2010 and 2024 using the keywords of"Parkinson's disease,alpha-synuclein,mitochondria,oxidative stress,calcium homeostasis,mitophagy,mitochondrial dynamics,mitochondrial protein introduction"in English.Finally,70 documents were included for review.RESULTS AND CONCLUSION:Recent studies have confirmed the important role of mitochondrial dysfunction in the pathophysiology of Parkinson's disease,and the interaction between α-synuclein and mitochondria is a particularly significant factor in the pathogenesis of Parkinson's disease.The cascade of events that begin with naturally unfolded α-synuclein and eventually form mature fibril is collectively known as α-synuclein aggregation.The toxicity of aggregation accumulates in dopaminergic neurons and then disrupts mitochondrial function,thereby triggering Parkinson's disease.Therefore,the underlying mechanism of this bidirectional relationship between α-synuclein and mitochondrial dysfunction may provide new insights into the pathophysiology of Parkinson's disease.
