The important role of the nervous system in regulating wound repair and scar healing
- VernacularTitle:神经系统在调控皮肤创伤修复和瘢痕愈合中的重要作用
- Author:
Jiamei SONG
1
;
Tingting LIU
;
Bin YAO
Author Information
- Publication Type:Journal Article
- Keywords: skin trauma; nerve regeneration; neurotransmitter; growth factor; nerve cells; angiogenesis; engineered skin tissue; engineered tissue construction
- From: Chinese Journal of Tissue Engineering Research 2025;29(18):3877-3884
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Skin wound repair is an extremely complex process.The nervous system plays an important role in regulating wound repair and scar healing.OBJECTIVE:To review the role of the nervous system in the process of skin wound repair,including the roles of related factors and various cells in the repair of skin injury.METHODS:The PubMed and CNKI databases were searched with the key words of"skin wound healing,nervous system,nerve regeneration,growth factor"in English and"skin wound healing,skin innervation,neuropeptide,growth factor,cell synergy"in Chinese.The time range of literature search was from 2003 to 2024,and 83 documents were finally included and analyzed.RESULTS AND CONCLUSION:(1)The skin is densely innervated by autonomic and sensory nerves,and there is growing evidence that the cutaneous nervous system is not only responsible for transmitting sensory information to the central nervous system,but also plays an important role in a variety of skin functions,including wound healing.(2)The nervous system acts on different stages of skin wound healing,which can regulate revascularization,promote the release of related growth factors and neurotransmitters,and cooperate with different types of cells to promote skin wound healing.Therefore,research on the underlying mechanisms of the nervous system has become a powerful target to promote skin wound healing.
