Mechanism by which melatonin promotes bone regeneration and its application in oral implantation
- VernacularTitle:褪黑素促进骨再生机制及在口腔种植中的应用
- Author:
Mingyi JI
1
;
Xinyi JI
;
Junfeng XU
Author Information
- Publication Type:Journal Article
- Keywords: melatonin; bone defect; bone regeneration; periodontitis; osseointegration; peri-implantitis; engineered bone remodeling
- From: Chinese Journal of Tissue Engineering Research 2025;29(18):3868-3876
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Alveolar bone defects can jeopardize patients'oral and jaw function and physical and mental health,and reduce their quality of life.Melatonin can be used for the prevention and treatment of bone defect diseases due to its properties of promoting bone regeneration,and also has important applications in osseointegration and peri-implant inflammation related to oral implants.OBJECTIVE:To explore the mechanism by which melatonin promotes bone regeneration,the potential application of melatonin in the field of oral implantation,and to provide new ideas for the utilization of melatonin's osteogenic properties in oral implantation.METHODS:With"melatonin,bone defect,osteoblast,osteoclast,reactive oxygen species,periodontitis,osseointegration,peri-implantitis"as Chinese and English search terms,the relevant literature was searched in CNKI and PubMed databases.The timeframe of the search was from January 2019 to August 2024,while a few classical early documents were included.Screening was carried out by reading the titles and abstracts,and 91 papers were finally included for review.RESULTS AND CONCLUSION:(1)Melatonin promotes bone regeneration by promoting the proliferation and differentiation of osteoblasts,chondrocytes and vascular endothelial cells,inhibiting bone resorption and limiting oxidative stress.(2)Melatonin,as a promoter of bone formation,plays a role in promoting osseointegration and preventing peri-implantitis in oral implants.(3)More research is needed in the future to completely reveal the osteogenic mechanisms of melatonin and to make guidelines for optimal administration conditions and safety of melatonin in osseointegration and peri-implantitis.
