Progress in porcine hemagglutinating encephalomyelitis
10.16303/j.cnki.1005-4545.2025.05.27
- VernacularTitle:猪血凝性脑脊髓炎研究进展
- Author:
Wenjie LI
1
;
Yongzhen JIN
;
Yumei SUN
;
Junchen ZHANG
;
Wenlong ZHU
;
Wen-tao LI
Author Information
1. 华中农业大学动物医学院,湖北武汉 430070;农业微生物资源发掘与利用全国重点实验,湖北武汉 430070;湖北洪山实验室,湖北武汉 430070
- Publication Type:Journal Article
- Keywords:
PHE;
PHEV;
epidemiology;
pathogenic mechanism
- From:
Chinese Journal of Veterinary Science
2025;45(5):1095-1102
- CountryChina
- Language:Chinese
-
Abstract:
Porcine hemagglutinating encephalomyelitis virus(PHEV),a betacoronavirus with a sin-gle-stranded,positive-sense RNA genome,is an important pathogen in the swine industry.It causes porcine hemagglutinating encephalomyelitis(PHE),presenting with symptoms such as vomiting,diarrhea,neurological symptoms,and respiratory distress,particularly in piglets.The virus is asso-ciated with high mortality rates and growth stunting in subclinical cases.PHEV has a well-docu-mented global distribution,with occurrences reported across Europe,South America,North Amer-ica,and East Asia,posing a considerable challenge to the swine industry.This review aims to pro-vide a comprehensive overview of PHE's virological characteristics,epidemiology,clinical and pathological manifestations,mechanisms of infection and pathogenicity,and the current state of di-agnostic techniques.It further evaluates advancements in vaccine and antiviral development,along-side comprehensive prevention and control strategies,contextualized within the framework of the latest foundational research.
