Research progress on the role of vitamin D and its signaling pathway in disease development
10.12173/j.issn.1005-0698.202409039
- VernacularTitle:维生素D及其信号通路在疾病中的作用研究进展
- Author:
Xiaomei ZHANG
1
;
Hui YE
;
Fang YANG
;
Rui MIN
;
Yeqing TONG
Author Information
1. 华中科技大学同济医学院公共卫生学院(武汉 430011)
- Publication Type:Journal Article
- Keywords:
Vitamin D;
Signaling pathways;
Occurrence of disease
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(4):456-466
- CountryChina
- Language:Chinese
-
Abstract:
Vitamin D is a fat-soluble vitamin primarily synthesized through skin exposure to ultraviolet B irradiation and dietary intake.Its biological effects are not limited to the regulation of calcium and phosphorus metabolism but also involve a variety of physiological functions such as immune modulation,anti-inflammation,and anti-tumor.In recent years,as research deepens,the role of the vitamin D signaling pathway in various diseases has been gradually revealed,and its regulatory mechanisms are complex and diverse.This paper systematically reviews the molecular mechanisms underlying the vitamin D signaling pathway,including the two-step hydroxylation activation process of vitamin D,the regulation of gene transcription mediated by the vitamin D receptor(VDR),the homeostatic regulation involving vitamin D-binding protein and metabolic enzymes such as 1α-hydroxylase and 24-hydroxylase,and interactions with other signaling pathways,including NF-κB,Wnt,and Hedgehog.This study highlights the role of vitamin D in various multi-system diseases such as inflammatory bowel disease,diabetes and its complications,obesity,cardiovascular disease,colorectal cancer,breast cancer,among others.The systematic cognitive framework for understanding the vitamin D signaling pathway was conducted,providing a theoretical basis for precision treatment strategies targeting VDR.
