Effect of flurbiprofen axetil on postoperative catheter-related bladder discomfort:a randomized,controlled,double-blind trial
10.12173/j.issn.1005-0698.202502015
- VernacularTitle:氟比洛芬酯对术后导尿管相关性膀胱刺激征的影响:一项随机对照双盲试验
- Author:
Zhidan LIU
1
;
Bo SONG
;
Liping LI
;
Yinhao GUO
;
Hongxia HE
;
Suihan XU
;
Yonghong ZHANG
;
Jun LI
Author Information
1. 西南医科大学临床医学院麻醉科(四川泸州 646000);电子科技大学医学院附属绵阳医院·绵阳市中心医院麻醉科(四川绵阳 621000)
- Publication Type:Journal Article
- Keywords:
Flurbiprofen axetil;
Transurethral resection of the prostate;
Catheter-related bladder discomfort;
Randomized controlled trial
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(4):373-379
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of intravenous flurbiprofen axetil on the incidence and severity of catheter-related bladder discomfort(CRBD)after transurethral resection of the prostate(TURP).Methods The elderly patients undergoing TURP under general anesthesia were enrolled,and randomly divided into two groups:flurbiprofen axetil group(group F)and control group(group C).Ten minutes before the end of surgery,group F was given 50 mg of flurbiprofen axetil intravenously,group C was given an equal amount of 0.9％sodium chloride injection.The primary outcome indicator was the incidence of moderate to severe CRBD immediately after entering the resuscitation room(T0).Secondary indicators included the incidence and severity of CRBD at 1 h(T1),2 h(T2),and 6 h(T3)after entering the resuscitation room,the amount of sufentanil used within 24 hours after surgery,postoperative NRS score,flurbiprofen axetil-related and analgesic adverse reactions 24 hours after surgery,and patient satisfaction.Results A total of 90 patients were included and each group was 45 patients.The incidence of moderate to severe CRBD at T0 was significantly lower in group F than that in group C(8.9％vs.33.3％,P=0.004).The incidence of CRBD in T1,T2,and T3 was lower in group F than in group C(P＜0.05).The incidence of mild CRBD at T3 in group F was lower than that in group C(P＜0.05).The incidence of moderate to severe CRBD at T1 and T2 in groups F was lower than that in group C(P＜0.05).The amount of sufentanil used in group F at 24 hours after surgery was significantly lower than that in group C(P=0.001).The pain scores in group F at T0,T1,T2,and T3 were lower than those in group C(P＜0.05);The postoperative patient satisfaction score in group F was higher than that in group C(P=0.001).However,there were no significant differences between the two groups in postoperative anesthesia resuscitation time and 24-hour adverse reactions incidence(P＞0.05).Conclusion Intravenous flurbiprofen axetil can safely and effectively reduce the incidence and severity of CRBD after TURP.It can significantly relieve pain,reduce sufentanil use,and have high clinical application value.
