Repair effects of graphene far-infrared irradiation on immune damage induced by cisplatin chemotherapy in Lewis lung cancer mice
10.13431/j.cnki.immunol.j.20240071
- VernacularTitle:石墨烯远红外对Lewis肺癌荷瘤小鼠顺铂化疗免疫损伤的修复作用
- Author:
Chen WANG
1
;
Yongchao FAN
;
Xiang MU
;
Zihan ZHAO
;
Mengyu FAN
;
Ge REN
;
Bo FENG
;
Qian ZHANG
Author Information
1. 102206,北京农学院动物科学技术学院兽医学(中医药)北京市重点实验室
- Publication Type:Journal Article
- Keywords:
Graphene;
Tumor bearing mice;
Tumor suppression rate;
Immunosuppression;
Immune repair
- From:
Immunological Journal
2024;40(6):520-525
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to investigate the effect of graphene far-infrared irradiation on the relevant immune indexes of Lewis lung cancer tumor bearing mice after cisplatin chemotherapy.A lung cancer tumor-bearing mouse immune damage model was established in Lewis mice,and the model mice were divided into a model control group(CTL),a chemotherapy group(DDP),a low-power graphene group(G-Low,30℃),and a high-power graphene group(G-High,35℃).Mice in all groups were subjected to detect the tumor volume growth rate,thymus index and spleen index,spleen lymphocyte proliferation activity and NK cell killing activity,the number of white blood cells in the peripheral blood and the ratio of CD4+T/CD8+T in the peripheral blood.Compared with the CTL group,the thymus index and spleen index of the DDP group were significantly lower(P＜0.01);compared with the DDP group,the tumor inhibition rate of the G-Low group was significantly improved(P＜0.05),and the tumor inhibition rate of the G-High group was extremely significantly improved(P＜0.01).The thymus index,white blood cell count,peripheral blood CD4+T/CD8+T ratio,and NK cell killing activity of the spleen in the G-High group were significantly higher than those in the DDP group(P＜0.05).Taken together,Graphene far-infrared irradiation has a good repair effect on the immune damage caused by cisplatin chemotherapy in Lewis lung cancer tumor-bearing mice,and can significantly inhibit tumor growth.
