Clinical characteristics of liver injury induced by different types of drugs and Logistic analysis of the influencing factors on the prognosis
10.12173/j.issn.1005-0698.202411059
- VernacularTitle:不同类别药物致肝损伤的临床特征及预后因素Logistic回归分析
- Author:
Yafei ZHANG
1
;
Yi CAO
1
;
Zhihao WANG
1
;
Yuanyuan WANG
1
Author Information
1. 安徽医科大学第二附属医院药学部(合肥 230601)
- Publication Type:Journal Article
- Keywords:
Drug-induced liver injury;
Clinical characteristics;
Medication history;
Prognosis analysis;
Influencing factors
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(4):410-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of drug-induced liver injury(DILI)caused by different drug categories,and to investigate factors influencing DILI prognosis.Methods Medical records of DILI patients diagnosed in our hospital from January 1,2019 to December 31,2023 were retrospectively collected.Clinical characteristics of DILI induced by different drug categories were analyzed.Multivariate Logistic regression was employed to identify prognostic factors of DILI.Results A total of 347 DILI patients were included.The predominant DILI pattern was hepatocellular injury(67.15％),followed by cholestatic(20.46％)and mixed types(12.39％).The top three causative drug categories were traditional Chinese medicine(25.34％),antineoplastic drugs(24.15％)and anti-infective agents(21.26％).Regarding prognosis outcomes,7 cases(2.02％)achieved complete recovery,269 cases(77.52％)showed improvement,and 71 cases(20.46％)demonstrated no improvement.Significant differences were observed among prognosis groups in age,gender,alanine aminotransferase level,aspartate transaminase level,alkaline phosphatase levels,DILI patterns,number of combined hepatoprotective drugs used,and causative drug categories(P＜0.05).Multivariate analysis revealed that cholestatic type[OR=0.237,95％CI(0.083,0.673),P=0.007]and combination therapy with＞2 hepatoprotective drugs[OR=0.551,95％CI(0.295,0.998),P=0.018]were independent risk factors for prognosis.Conclusion The number of hepatoprotective drugs used in combination and DILI patterns may serve as potential indicators for prognosis evaluation.Particular attention should be paid to the hepatotoxicity of traditional Chinese medicine,antineoplastic agents,and anti-infective drugs.Rational drug selection is essential for improving DILI prevention and treatment.
