Research status of traditional Chinese medicine intervention in precancerous lesions of gastric cancer

VernacularTitle:中药干预胃癌前病变作用的研究现状
Author: Peng-cheng DOU ¹ ; Rui-ping SONG ; Liu-yi YAO ; Jiao-jiao ZUO ; Zhuang-zhuang FENG ; Xin-yi CHEN ; Xiao-long WANG ; Jin SHU
Author Information

1. 甘肃中医药大学中医临床学院,甘肃兰州 730030
Publication Type:Journal Article
Keywords: traditional Chinese medicine; precancerous lesions of gastric cancer; mechanism of action
From: The Chinese Journal of Clinical Pharmacology 2024;40(22):3343-3347
CountryChina
Language:Chinese
Abstract: Precancerous lesions of gastric cancer(PLGC)is a key pathological stage in the process of inflammation cancer transformation of the gastric mucosa.Early diagnosis and effective intervention in this stage have positive significance in preventing the occurrence of gastric cancer.Numerous studies have confirmed that traditional Chinese medicine can effectively intervene in PLGC by regulating cell proliferation and apoptosis,regulating inflammatory response,anti angiogenesis,inhibiting epithelial mesenchymal transition,inhibiting glycolysis,antioxidant stress,combating helicobacter pylori,regulating autophagy levels,and regulating gut microbiota through various pathways.The article systematically elaborates on the research status of the intervention mechanism of traditional Chinese medicine monomers or extracts,and traditional Chinese medicine formulas in PLGC,aiming to provide reference for the clinical treatment of this disease and related drug development.