Research status of raditional Chinese medicine-induced ferroptosis for digestive system tumors
10.13699/j.cnki.1001-6821.2024.22.024
- VernacularTitle:中医药诱导铁死亡治疗消化系统肿瘤的研究现状
- Author:
Wei-peng LI
1
;
Feng-chi LIN
;
Long-fei FENG
;
Tao WANG
;
Huan GUO
;
Hai-xiang SU
Author Information
1. 甘肃中医药大学基础医学院,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
digestive system;
cancer;
oxidative stress;
ferroptosis
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(22):3338-3342
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine combined with modem medicine,such as surgery,chemotherapy,radiotherapy and others,play an increasingly important role in the treatment of digestive system cancers.The research on the therapeutic mechanism of traditional Chinese medicine for digestive system tumors involves many aspects.One of these mechanism is that traditional Chinese medicine can induce the programmed cell death of cancer cells.Programmed cell death includes apoptosis,programmed necrosis,pyroptosis and ferroptosis.Ferroptosis is closely related to the cell death caused by the production of lipid peroxides which are catalyzed over ferric divalent and ester oxygenase on the cell membrane and the cell oxidative stress.In order to provide the new ideas for better development and utilization of traditional Chinese medicine in the treatment of digestive system cancers,this paper reviews the research progress on the anti-cancer mechanism of traditional Chinese medicine through inducing the cancer cell ferroptosis.
