Protective effect of Angelica sinensis polysaccharide on Leptospiral infection in golden hamster
10.16303/j.cnki.1005-4545.2025.05.23
- VernacularTitle:当归多糖在金黄地鼠感染钩端螺旋体中的保护作用
- Author:
Lingling GONG
1
;
Tianbao LYU
1
;
Hua TIAN
1
;
Hongkai HE
1
;
Yue DING
1
;
Jiuxi LIU
1
;
Xufeng XIE
1
;
Wenlong ZHANG
1
;
Yongguo CAO
1
Author Information
1. 吉林大学动物医学学院人兽共患传染病重症诊治全国重点实验室,吉林长春 130062
- Publication Type:Journal Article
- Keywords:
Leptospira;
Angelica sinensis polysaccharide;
hamster;
infection
- From:
Chinese Journal of Veterinary Science
2025;45(5):1060-1066
- CountryChina
- Language:Chinese
-
Abstract:
To explore the protective effect of Angelica sinensis polysaccharide(ASP)on leptospiro-sis induced by pathogenic Leptospira infection,the golden hamster model of leptospirosis was se-lected for the experiment.The Leptospira and Leptospira+ASP groups were intraperitoneally injected with Leptospira interrogans serovar Lai strain 56601(1 × 10 6 per hamster).After infec-tion,the Leptospira+ASP group was injected intraperitoneally with ASP(50 mg/kg)for three consecutive days,while the Leptospira group was injected intraperitoneally with normal saline for three days.The experiment employed methods such as daily observation of the clinical symptoms of golden hamsters,statistics of the survival status of each group of golden hamsters,pathological damage of liver,kidney,and lung,bacterial load in organs,and the expression of inflammatory cy-tokines(IL-1β and TNF-α).The results indicated that ASP could effectively alleviate the clinical symptoms of the infected hamsters,enhance the survival rate,ameliorate the pathological damage of the body,reduce the bacterial load in various organs,and mitigate tissue inflammation.This study demonstrated for the first time that ASP has a protective effect on leptospirosis,providing medication guidance for the clinical treatment of leptospirosis.
