Analysis of the current situation of skin test for β-lactam antibiotics in medical institutions in Beijing
10.13699/j.cnki.1001-6821.2024.22.021
- VernacularTitle:北京市医疗机构β内酰胺类抗菌药物皮肤试验现状的分析
- Author:
Ying-qiu YING
1
;
Yi-feng DING
;
Yin-chu CHENG
;
Ming LU
;
Jia-jia ZHENG
;
Chao LIN
;
Ning SHEN
;
Chun-yan LI
;
Juan DU
;
Yi-heng YANG
;
Suo-di ZHAI
Author Information
1. 北京大学第三医院药学部,北京 100191;北京大学医学部药物评价中心,北京 100191;北京市药学质量控制和改进中心,北京 100191
- Publication Type:Journal Article
- Keywords:
β-lactams;
skin test;
cross-sectional study
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(22):3323-3327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the current situation of skin tests for β-lactams in 155 hospitals in Beijing.Methods The questionnaires were sent to medical institutions in Beijing to statistically described the current situation of β-lactams skin test,and the relevant influencing factors were analyzed by Fisher exact test,and Chi-square test.Results A total of 3 097 questionnaires were received from 155 medical institutions,of which 3 057 were valid questionnaires(effective rate is 98.71％).In this study,122 hospitals conducted skin test before using intravenous penicillins,accounting for 99.19％of 123 hospitals with intravenous penicillins.Hospitals with infectious disease pharmacists conducted more skin tests before using intravenous penicillins(98.59％vs 88.46％,P＜0.001),and some hospitals didn't conduct skin tests before using oral penicillins.Seventy hospitals(45.16％)had not yet cancelled skin tests for cephalosporins,more hospitals with infectious disease pharmacists cancelled routine skin test(59.74％vs 50.00％,P＜0.05),and more tertiary hospitals cancelled cephalosporin skin test(80.65％vs 51.40％,29.41％,all P＜0.01).After the promulgation of the"Guiding Principle for Skin Test of β-lactams(2021 edition)",more primary hospitals have developed or updated the rules or regulation for skin test of β-lactams according to the Guiding Principle,compared with secondary hospitals(72.22％vs 41.18％,P＜0.05).Hospitals with infectious disease pharmacists developed or updated the rules or regulation for skin test of β-lactams in their hospitals(78.57％vs 60.00％,P＜0.05).Infectious disease pharmacists had promoting effect on the publicity of the rules or regulation of skin test in the hospital(92.65％vs 80.46％,P＜0.05).Conclusion Many hospitals in Beijing have not cancelled cephalosporins skin test,and the current situation of cancelling cephalosporins skin test in tertiary hospitals is better than that in primary and secondary hospitals.
