Study on the Correlation between Sleep Disorder and Postoperative Pain,Inflammation Stress Response,and Cognitive Function in Patients with Primary Liver Cancer Undergoing TACE Operative
10.13241/j.cnki.pmb.2025.10.009
- VernacularTitle:睡眠障碍与原发性肝癌患者TACE术后疼痛、炎症-应激反应及认知功能的相关性研究
- Author:
Xiao-ming GU
1
;
Yu WANG
;
Cui-cui ZHANG
;
Min SHEN
Author Information
1. 山东省立第三医院肝胆外科 山东济南 250031
- Publication Type:Journal Article
- Keywords:
Sleep disorder;
Primary liver cancer;
Transcatheter arterial chemoembolization;
Pain;
Inflammation stress response;
Cognitive Function
- From:
Progress in Modern Biomedicine
2025;25(10):1676-1684
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the correlation between sleep disorder and postoperative pain,inflammation stress response,and cognitive function in patients with primary liver cancer undergoing transcatheter arterial chemoembolization(TACE)operative.Methods:80 patients with primary liver cancer who were treated in Shandong Provincial Third Hospital from July 2022 to July 2024 were selected,all patients underwent TACE operative.The patients were divided into non sleep disorder group and sleep disorder group according to the pittsburgh sleep quality index(PSQI)score 1 month postoperative.The visual analog scale(VAS),postoperative inflammatory mediators[serum interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-8(IL-8)],postoperative stress response[superoxide dismutase(SOD),malondialdehyde(MDA)],and mini-mental state examination(MMSE)scores between sleep disorder group and non sleep disorder group were compared.Pearson correlation analysis was used to investigate the correlation between sleep disorder and postoperative pain,inflammation stress response,and cognitive function in patients underwent TACE.Results:VAS score,IFN-γ,TNF-α,IL-1β,IL-8,and MDA in the sleep disorder group were higher than those in non sleep disorder group(P＜0.05).SOD and MMSE score in sleep disorder group were lower than those in non sleep disorder group(P＜0.05).Pearson correlation analysis results showed that,sleep disorder were negatively correlated with SOD and MMSE,while positively correlated with VAS score,IFN-γ,TNF-α,IL-1β,IL-8,and MDA(P＜0.05).Conclusion:The incidence of sleep disorder is higher in patients with primary liver cancer TACE postoperative,and sleep disorder can exacerbate postoperative pain and inflammation stress response in patients undergoing TACE operative,and affect cognitive function.
