Relationship between Serum IL-33,IRAK4,CCR5 Expression Levels and Patients with Traumatic Cerebral Hemorrhage Complicate with Acute Ischemic Stroke
10.13241/j.cnki.pmb.2025.10.005
- VernacularTitle:血清IL-33、IRAK4、CCR5表达水平与创伤性脑出血患者并发急性缺血性脑卒中的关系
- Author:
Gang WANG
1
;
Huan WANG
1
;
Fei GAO
1
Author Information
1. 沈阳医学院附属中心医院神经外二科 辽宁沈阳 110024
- Publication Type:Journal Article
- Keywords:
Interleukin-33;
Interleukin-1 receptor-associated kinase 4;
C-C chemokine receptor 5;
Traumatic cerebral hemorrhage;
Acute ischemic stroke
- From:
Progress in Modern Biomedicine
2025;25(10):1641-1648,1675
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between serum interleukin-33(IL-33),interleukin-1 receptor-associated kinase 4(IRAK4),C-C chemokine receptor 5(CCR5)expression levels and patients with traumatic cerebral hemorrhage(TCH)complicate with acute ischemic stroke(AIS).Methods:162 TCH patients who were admitted to our hospital from March 2022 to January 2024 were selected,the patients were divided into AIS group and non-AIS group according to whether there was AIS in the early postoperative period.Serum IL-33,IRAK4 and CCR5 expression levels in AIS and non-AIS groups were compared,the predictive value of serum IL-33,IRAK4 and CCR5 expression levels in patients with TCH complicate with AIS was analyzed by receiver operating characteristic(ROC)curve,and the influencing factors of patients with TCH complicate with AIS were analyzed by multi-factor Logistic regression model.Results:Serum L-33,IRAK4 and CCR5 expression levels in AIS group were higher than those in non-AIS group(P＜0.05).Patients with TCH complicate with AIS were associated with Glasgow coma scale(GCS)score at admission,cerebral xenon,intraoperative hiatus incision and perioperative hypotension(P＜0.05).Low GCS score at admission,cerebral xenon,intraoperative hiatus incision,perioperative hyhyemia,high IL-33,high IRAK4 and high CCR5 were risk factors for patients with TCH complicate with AIS(P＜0.05).The ROC curve showed that the combination of serum IL-33,IRAK 4 and CCR5 had higher predictive value of patients with TCH complicate with AIS than testing alone(P＜0.05).Conclusion:Low GCS score at admission,cerebral xenon,intraoperative hiatus incision,perioperative hypostasis,high IL-33,high IRAK4 and high CCR5 are risk factors for patients with TCH complicate with AIS,and the predictive value of IL-33,IRAK4 and CCR5 for patients with TCH complicate with AIS is high.
