Advancements in the application of biologics for rheumatic autoim-mune diseases in pregnancy
10.12092/j.issn.1009-2501.2024.12.009
- VernacularTitle:生物制剂在妊娠合并风湿免疫性疾病中的应用进展
- Author:
Xiaoshi ZHOU
1
;
Shiran LI
;
Siyu ZENG
;
Guolin LI
;
Changji ZHANG
;
Yong YANG
Author Information
1. 电子科技大学附属医院·四川省人民医院药学部,成都 610072,四川;四川省医学科学院·四川省人民医院/电子科技大学医学院个体化药物治疗四川省重点实验室,成都 610054,四川
- Publication Type:Journal Article
- Keywords:
pregnancy;
rheumatic autoimmune diseases;
biologics
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(12):1389-1400
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatic autoimmune diseases are chronic conditions affecting multiple systems,pre-dominantly occurring in young women of childbear-ing age.Given the nature of diseases and unique physiological changes during pregnancy,they may adversely impact pregnancy outcomes and endan-ger maternal and fetal health.In recent years,with the deepening of immunological research,biologi-cally targeted therapy has gradually become a fo-cus of attention in the treatment of rheumatic au-toimmune diseases in pregnancy.Biologics effec-tively alleviate disease symptoms,mitigate preg-nancy complications,and improve adverse preg-nancy outcomes by targeting pivotal inflammatory factors.The review systematically discusses the structure and pharmacokinetic characteristics of bi-ologics,and comprehensively reviews the current application and future prospects in managing rheu-matic autoimmune diseases in pregnancy based on their specific targets.It aims to provide scientific references and guidance on the safe administration of medications and therapeutic strategies for these patients,ultimately enhancing health outcomes for mothers and infants.
