Advances in diagnosis,treatment and management of hypertriglycer-idemia in pregnancy
10.12092/j.issn.1009-2501.2024.12.008
- VernacularTitle:妊娠合并高甘油三酯血症诊治和管理研究进展
- Author:
Zhimin LI
1
;
Shiran LI
;
Jingxian XIE
;
Jiao ZHANG
;
Pengfei LI
;
Siyu ZENG
;
Yong YANG
Author Information
1. 四川省医学科学院·四川省人民医院/电子科技大学附属四川省人民医院药学部,成都 610072,四川;电子科技大学医学院个体化药物治疗四川省重点实验室,成都 610054,四川
- Publication Type:Journal Article
- Keywords:
hypertriglyceridemia;
pregnancy;
pregnancy complications
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(12):1380-1388
- CountryChina
- Language:Chinese
-
Abstract:
Hypertriglyceridemia(HTG)during pregnancy may cause serious complications such as acute pancreatitis,gestational diabetes mellitus,and preeclampsia,especially the high mortality rate of maternal acute pancreatitis is of concern.The physiologic increase in triglyceride(TG)levels during pregnancy poses a challenge for the diagno-sis of HTG,there are no diagnostic criteria for preg-nant women.The management of HTG in pregnan-cy remains focused on early screening and a scien-tifically based fat-restricted diet.Omega-3 fatty ac-id therapy may be considered for those who can-not be controlled after strict dietary restriction and lifestyle changes,and fibrates may be used in late pregnancy when the benefits outweigh the risks,as appropriate,and plasma exchange may be a safe and effective option for extremely severe patients.TG levels in early pregnancy are associated with maternal postpartum and neonatal prognosis.Fur-ther studies on pharmacologic treatments and management for HTG in pregnancy are expected.
