Advances in population pharmacokinetics of voriconazole in special populations

VernacularTitle:特殊人群应用伏立康唑的群体药动学研究进展
Author: Xuerong YANG ¹ ; Jing FANG ; Lu CHEN ; Yong YANG
Author Information

1. 成都市第六人民医院药剂科,成都 610051,四川
Publication Type:Journal Article
Keywords: voriconazole; population pharmacoki-netics; special populations; children; liver cirrhosis
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2024;29(12):1367-1379
CountryChina
Language:Chinese
Abstract: Voriconazole(VRC)is a broad-spec-trum triazole antifungal drug used for the systemic prophylaxis and treatment of invasive fungal infec-tions(IFI)in adults and children.However,VRC has a typical nonlinear pharmacokinetic profile and highly variable inter-and intra-individual variability,limiting its rational clinical use.Special populations have even greater variation due to physiologic rea-sons,especially younger pediatric patients,with less evidence and greater limitations in the use of VRC.In recent years more and more VRC popula-tion pharmacokinetic(PPK)research results have been published,identifying many covariates,which provides ideas and methods for the rational use of VRC.Based on the latest national and international research results,this article introduced the latest progress of PPK of VRC applied to special popula-tions and demonstrated how PPK could be used to adjust the dose and optimize the treatment.