Clinical study on model-guided vancomycin plasma concentration monitoring
10.12092/j.issn.1009-2501.2024.12.004
- VernacularTitle:模型引导下的万古霉素血药浓度监测临床研究
- Author:
Shixuan YUAN
1
;
Ziyan LV
1
;
Yong YANG
1
;
Lu CHEN
1
;
Lijuan ZHANG
1
Author Information
1. 四川省医学科学院·四川省人民医院药学部,成都 610072,四川;电子科技大学医学院,个体化药物治疗四川省重点实验室,成都 610072,四川
- Publication Type:Journal Article
- Keywords:
model-guided precision medication;
vancomycin;
therapeutic drug monitoring
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(12):1344-1352
- CountryChina
- Language:Chinese
-
Abstract:
AIM:The purpose of this paper is to study whether the precise administration of vanco-mycin under the guidance of the model can achieve better clinical treatment effect by imple-menting the precise medication model in Sichuan Provincial People's Hospital,so as to promote its wide application in practice.METHODS:A prospec-tive cohort study was conducted.The experimental group was patients who used the Model-informed Precision Dosing to determine the vancomycin dos-ing regimen,and the control group was patients who only decided the vancomycin dosing regimen based on the existing diagnosis and treatment pro-cess.Two sets of data were matched to compare whether there were significant differences be-tween the two groups of patients in the TDM steady-state trough concentration or the steady-state AUC compliance ratio,and to evaluate the ap-plication value of the model software.RESULTS:Ac-cording to the inclusion and exclusion criteria,the steady-state blood concentration data of vancomy-cin in a total of 280 patients were used for analysis.The final result of the experiment was that the number of people in the experimental group was 10,and the compliance rate was 62.50％.There were 64 cases in the control group,and the compli-ance rate was 24.24％(P=0.002).CONCLUSION:The study found that the model-guided precise dos-ing regimen can more accurately control the blood concentration of vancomycin in patients,and signif-icantly improve the patient's steady-state trough concentration compliance rate.Therefore,it is rec-ommended to increase the research on the pro-gram and promote its wide application in clinical practice.
