Research and application of personalized treatment of severe infec-tion patients with Meropenem based on TDM
10.12092/j.issn.1009-2501.2024.12.002
- VernacularTitle:美罗培南基于TDM个体化治疗重症感染患者的研究应用
- Author:
Wenjuan WANG
1
;
Peiyuan LU
;
Xiaotong YANG
;
Li CHEN
;
Yinzhi ZHAO
;
Yuan YUAN
Author Information
1. 甘肃中医药大学,第一临床医学院
- Publication Type:Journal Article
- Keywords:
meropenem;
TDM;
severe infection;
renal dysfunction
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(12):1329-1336
- CountryChina
- Language:Chinese
-
Abstract:
Severe infection is a significant threat to patient safety and survival.As the main treat-ment for hospital acquired infections,meropenem is limited in its effectiveness due to the emergence of drug resistance,especially after long-term use of antibiotics.Therefore,optimizing the efficacy of an-tibiotics such as meropenem and avoiding microbi-al resistance has become an urgent issue to be ad-dressed.Therapeutic drug monitoring(TDM),as an important tool for achieving personalized drug ad-ministration,is increasingly recognized as an impor-tant strategy for optimizing antibiotic concentra-tion,avoiding treatment failure and toxicity in criti-cally ill patients and patients with renal insufficien-cy.By reviewing the current application status,pharmacokinetics,and TDM guidance of meropen-em,clinical references are provided for the treat-ment of critically ill patients and patients with renal insufficiency,and guidance and support are provid-ed for optimizing antibiotic treatment.
