Research progress in vaccines for rough Brucella
10.3969/j.issn.1002-2694.2025.00.038
- VernacularTitle:粗糙型布鲁氏菌疫苗的研究进展
- Author:
Qian WANG
1
;
Xiang-cheng PI
;
Yu FENG
;
Renbilige NA
;
Hui JIANG
Author Information
1. 中国农业科学院北京畜牧兽医研究所,北京 100193;山东农业大学动物医学院,泰安 271018
- Publication Type:Journal Article
- Keywords:
brucellosis;
rough;
Brucella;
vaccine
- From:
Chinese Journal of Zoonoses
2025;41(3):263-268
- CountryChina
- Language:Chinese
-
Abstract:
Brucellosis,a zoonotic infectious disease caused by Brucella,leads to persistent infections in both animals and humans.This disease not only substantially affects the health and development of the livestock industry,but also poses a major threat to human health and public safety.Currently,vaccination remains the most effective method for preventing animal bru-cellosis.Compared with smooth strains,rough Brucella strains lack the O-chain antigens,thus offering advantages such as lower virulence,higher safety,and no interference with clinical diagnostics.Consequently,rough Brucella vaccines have prom-ising potential for brucellosis prevention and control.Researchers are now focusing on the development of Brucella abortus vac-cines as an important direction in brucellosis vaccine research and development.An urgent need exists for the development of Brucella abortus vaccines.This article provides a brief review of current research on vaccines for rough Brucella and candidate strains,and summarizes developed vaccine applications and their effectiveness,to provide insights for brucellosis prevention and control,and further development of vaccines for rough Brucella.
