Comparison of clinical features and prognosis of patients with acute cerebral infarction with different levels of erythrocyte distribution width coefficient of variation
10.3760/cma.j.cn115455-20240105-00020
- VernacularTitle:不同水平红细胞分布宽度变异系数的急性脑梗死患者临床特征及预后比较
- Author:
Yandong WU
1
;
Wufuer ALIMU·
1
;
Shan RU
1
;
Tingting LI
1
;
Wenli SHI
1
Author Information
1. 新疆医科大学第一附属医院神经内科，乌鲁木齐 830000
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Prognosis;
Coefficient of variation of erythrocyte distribution width;
Clinical features;
Correlation
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(6):498-502
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical features and prognosis of patients with acute cerebral infarction with different variation coefficients of red blood cell distribution width.Methods:A total of 1 080 patients with acute cerebral infarction diagnosed and treated in the First Affiliated Hospital of Xinjiang Medical University from July 2021 to May 2023 were retrospectively selected as the study objects. The coefficient of variation of red blood cell distribution width was determined for all patients, among which 361 patients with the coefficient of variation of red blood cell distribution width was 11.91% to 14.89%(normal group), and 719 patients with the coefficient of variation of red blood cell distribution width was 14.90% to 23.76% (abnormal group). The clinical characteristics and prognosis of patients with acute cerebral infarction with different coefficient of variation of red blood cell distribution width were compared. Spearman test and Pearson test were used to analyze the correlation between the variation coefficient of red blood cell distribution width and clinical characteristics and prognosis of patients with acute cerebral infarction.Results:There were no significant differences in the proportion of cardiac embolism, arteriole occlusion, partial anterior circulation infarction, posterior circulation infarction and lacunar infarction between the two groups ( P>0.05). The proportion of large atherosclerosis, total anterior circulation infarction, recurrent infarction and prognosis grade 4, 5 and 6 in the normal group was lower than those in the abnormal group :48.48% (175/361) vs. 55.22% (397/719), 8.31% (30/361) vs. 96/719 (13.35%), 16.90% (61/361) vs. 25.03% (180/719), 11.91% (43/361) vs. 42.84% (308/719), 5.26% (19/361) vs. 11.68% (84/719), 0.83% (3/361) vs. 7.93% (57/719); the proportion of grade 0, 1 and 2 prognosis in the normal group were higher than that in the abnormal group: 13.85% (50/361) vs. 0.42% (3/719), 21.05% (76/361) vs. 4.17% (30/719), 21.88% (79/361) vs. 4.73% (34/719), there were statistical differences ( P<0.05). There were statistically significant differences in the variation coefficient of red cell distribution width in patients with acute cerebral infarction among different disease inducements, infarct parts, incidence times and prognosis grades ( P<0.05). Spearman test showed that the variation coefficient of red blood cell distribution width was positively correlated with the infarct volume in patients with acute cerebral infarction ( r = 0.591, P<0.05). The results of Pearson test showed that the variation coefficient of red blood cell distribution width was not correlated with the cause of disease and the location of infarction in patients with acute cerebral infarction ( P>0.05), but was positively correlated with the frequency of incidence and prognosis grade ( r = 0.079, 0.402, P<0.05). Conclusions:Higher coefficients of variation of erythrocyte distribution width are associated with larger infarct size, higher risk of recurrence, and worse prognosis in acute cerebral infarction.
