Repeated attacks of type Ⅱ Kounis syndrome caused by allergic reactions to multiple drugs
10.3760/cma.j.cn114015-20220930-00888
- VernacularTitle:多种药物过敏致Ⅱ型Kounis综合征反复发作
- Author:
Juanjuan ZHENG
1
;
Xinyuan LIU
1
;
Bingqing LI
1
;
Jing XU
1
;
Xiaoyu LI
1
Author Information
1. 青岛大学附属医院消化内科，青岛 266003
- Publication Type:Journal Article
- Keywords:
Anaphylaxis;
Kounis syndrome;
Acute coronary syndrome
- From:
Adverse Drug Reactions Journal
2023;25(6):371-373
- CountryChina
- Language:Chinese
-
Abstract:
A 70-year-old male patient suddenly developed itching all over the body, severe chest pain, and radiating pain in the left upper limb, accompanied by urticarial, 4 hours after endoscopic polypectomy of colon and during the intravenous infusion of 5% glucose injection. His blood pressure was 85/50 mmHg, heart rate was 95-106 beats/min, and the heart rhythm is absolutely irregular. Electrocardiogram showed ST segment elevation in leads V 2~V 6. Coronary angiography showed an occlusion in the middle segment of the left anterior descending artery, and one stent was implanted after aspiration of the thrombus. Then his symptoms were improved. On day 12 after endoscopic polypectomy of colon, the patient suddenly lost consciousness and blood pressure could not be measured one minute after subcutaneous injection of sulfoda hepatokitae sodium 1.5 mg. Anaphylactic shock was considered. After receiving antiallergic, raising blood pressure, and enhancing cardiac function treatments, the patient′s consciousness and blood pressure restored. On day 14 after endoscopic polypectomy of colon, the patient developed pruritus, rash, chest tightness, suffocation, and decreased blood pressure after the 6th intravenous injection of tolasemide 10 mg for 5 minutes. Immediate antiallergic treatments were given and the symptoms were improved. Combined with the history and skin prick test results, the patient was considered to have repeated attacks of type II Kounis syndrome.
