Optimization of Extraction Process for Organic Acids from Picris hieracioides L.using Deep Eutectic Solventy by Response Surface Methodology
10.3870/j.issn.1004-0781.2025.06.016
- VernacularTitle:响应面法优化低共熔溶剂提取毛连菜中有机酸的提取工艺
- Author:
Fang YE
1
;
Wenjing PENG
;
Xuwen YE
;
Xueqin WANG
;
Wei LU
;
Tao ZHENG
;
Liangyong HUANG
Author Information
1. 湖北医药学院附属十堰市太和医院药学部,十堰 442000;湖北医药学院药学院,十堰 442000
- Publication Type:Journal Article
- Keywords:
Picris hieracioides L.;
Deep eutectic solvents;
Chlorogenic acid;
Isochlorogenic acid A;
Isochlorogenic acid B;
Isochlorogenic acid C;
Response surface methodology
- From:
Herald of Medicine
2025;44(6):934-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the extraction process of chlorogenic acid and three other organic acids from Picris hieracioides L.with deep eutectic solvents using response surface methodology.Methods By comparing the extraction rate of organic acids in seven deep eutectic solvents,the best solvent combinations were identified,and the optimal extraction process of organic acids from Picris hieracioides L.was obtained by optimizing the liquid/feed ratio,extraction temperature,extraction time and other parameters using the response surface method on the basis of a one-way experiment.Results The deep eutectic solvent with 30%water content(choline chloride∶urea=1∶2)was effective in extracting organic acids from Picris hieracioides L.The optimal extraction process optimized by response surface method was:extraction temperature 30℃,extraction time 30 min,liquid-solid ratio 20∶1(mL·g-1),the extraction rate of organic acids under this condition was 1.092 9%.Conclusion The deep eutectic solvent optimized through response surface methodology is an efficient,green and eco-friendly extraction method.This study provides a theoretical foundation for the subsequent development and utilization of Picris hieracioides L..
