Allergic purpura due to linazolamide glucose injection
10.3760/cma.j.cn114015-20220613-00523
- VernacularTitle:利奈唑胺葡萄糖注射液致过敏性紫癜
- Author:
Yan CHEN
1
;
Shenshen YANG
1
;
Zimin WANG
1
;
Weihua WANG
1
Author Information
1. 首都医科大学宣武医院老年医学综合科，北京 100053
- Publication Type:Journal Article
- Keywords:
Purpura, Schoenlein-Henoch;
Drug-related side effects and adverse reactions;
Linezolid
- From:
Adverse Drug Reactions Journal
2023;25(6):379-381
- CountryChina
- Language:Chinese
-
Abstract:
A 98-year-old male patient received cefoperazone sodium and sulbactam sodium and ambroxol etc. due to pulmonary infection. Before treatments, the patient′s coagulation function was basically normal, and the platelet count was within the reference range. Due to poor anti-infection effect, cefoperazone sodium and sulbactam sodium was changed to voriconazole combined with piperacillin sodium and tazobactam sodium 13 days later, which was adjusted to voriconazole, meropenem and linezolid glucose injection 7 days later. Three days after linezolid administration, the patient′s temperature was 39.3 ℃, and scattered dark red petechiae appeared on his both hands, upper limbs, shoulders and back, with some appearing as patchy ecchymosis, without tenderness pain and fading when pressing. Laboratory tests showed that prothrombin time was 18.4 s, international normalized ratio was 1.50, activated partial thromboplastin time was 53.6 s, fibrinogen was 5.11 g/L, and plasma D-dimer was 4.27 mg/L. It was considered to be allergic purpura, which might be related to linezolid glucose injection. The drug was stopped and replaced by tigecycline, and the treatment such as anti-allergy, fluid replacement, and plasma infusion were given. Eleven days later, the patient′s skin petechiae and ecchymosis disappeared. Laboratory tests showed prothrombin time 16.2 s, international normalized ratio 1.28, activated partial thromboplastin time 35.6 s, fibrinogen 2.62 g/L, and plasma D-dimer 2.48 mg/L.
