Advances in Mechanistic and Translational Applications of Anti-CGRP/CGRP Receptor Antibodies

VernacularTitle:CGRP/CGRPR抗体药物作用机制及应用研究进展
Author: Cong XING ¹ ; Fenghao PENG ; Chunxia QIAO ; Mengdie LYU
Author Information

1. 河南大学抗体药物开发技术国家地方联合工程实验室,开封 475004
Publication Type:Journal Article
Keywords: Calcitonin gene-related peptide; Calcitonin gene-related peptide receptor; Antibodies
From: Herald of Medicine 2025;44(6):912-917
CountryChina
Language:Chinese
Abstract: Calcitonin gene-related peptides(CGRP)are peptides that are ubiquitous in the central and peripheral nervous systems,which has been shown to be associated with pain,setting off a boom in the development of chemical small molecule antagonists targeting CGRP receptors,but most of them have failed due to greater hepatotoxicity.Anti-CGRP/CGRPR antibodies have attracted widespread attention due to their high specificity and safety,especially lower hepatotoxicity.This article reviews the structure and function of CGRP and its receptors,as well as the research progress of anti-CGRP-related neutralizing antibodies in order to provide a reference for the exploration of disease mechanisms and drug development related to CGRP.