Study on the Relationship between the Expression of miR-19a-3p and miR-23b-3p in Prostate Cancer Tissues and Clinicopathological Parameters and Prognosis
10.13241/j.cnki.pmb.2025.10.003
- VernacularTitle:前列腺癌组织miR-19a-3p和miR-23b-3p表达与临床病理参数和预后的关系研究
- Author:
Yuan-feng FAN
1
;
Jun ZHANG
1
;
Da-jin ZHU
1
;
Yun-feng ZHOU
1
Author Information
1. 盐城市第一人民医院泌尿外科 江苏盐城 224000
- Publication Type:Journal Article
- Keywords:
Prostate cancer;
miR-19a-3p;
miR-23b-3p;
Clinicopathological parameters;
Prognosis
- From:
Progress in Modern Biomedicine
2025;25(10):1620-1627
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the expression of microribonucleic acid(miR)-19a-3p and miR-23b-3p in prostate cancer tissues and clinicopathological parameters and prognosis.Methods:135 prostate cancer patients who were admitted to our hospital from January 2019 to October 2021 were selected,all patients underwent radical prostatectomy or radical prostatectomy plus lymph node dissection,surgically resected cancer tissues and adjacent tissues were taken,and the expression of miR-19a-3p and miR-23b-3p were detected.The patients were followed up for 3 years after discharge,the survival curve was drawn by Kaplan-Meier,and the factors affecting the prognosis of prostate cancer patients were analyzed by COX regression.Results:The expression of miR-19a-3p and miR-23b-3p in cancer tissues of prostate cancer patients were lower than those in adjacent tissues(P＜0.05).the expression of miR-19a-3p and miR-23b-3p in prostate cancer tissues with tumor stage pT3-4,gleason grade Gleason 3-5 and lymph node metastasis was lower than that in prostate cancer tissues with tumor stage pT1-2,Gleason 1-2 and no lymph node metastasis(P＜0.05).3 cases were lost to follow-up,20 cases died and 112 cases survived.The 3 years overall survival(OS)rate in prostate cancer patients with low expression of miR-19a-3p and low expression of miR-23b-3p was lower than that in prostate cancer patients with high expression of miR-19a-3p and high expression of miR-23b-3p(P＜0.05).Lymph node metastasis was a risk factor for poor prognosis in prostate cancer patients(P＜0.05),and high expression of miR-19a-3p and miR-23b-3p were protective factors(P＜0.05).Conclusion:The expression of miR-19a-3p and miR-23b-3p in prostate cancer tissues is down-regulated,and is associated with high tumor stage and histological grade,lymph node metastasis and low survival rate.
