Analgesic Effect of Esketamine Combined with Ultrasound-Guided Sciatic Nerve Block on Elderly Patients with Lower Limb Fractures and its Impact on Vital Signs and Sleep Quality
10.13241/j.cnki.pmb.2025.09.015
- VernacularTitle:艾司氯胺酮联合超声引导下坐骨神经阻滞对老年下肢骨折患者的镇痛效果及对生命体征、睡眠质量的影响
- Author:
Ze YU
1
;
Yi JIANG
1
;
Bin LI
1
Author Information
1. 华润辽健集团阜新矿总医院麻醉科 辽宁 阜新 123000
- Publication Type:Journal Article
- Keywords:
Esketamine;
Ultrasound;
Sciatic nerve block;
Elderly;
Lower limb fracture;
Vital signs;
Sleep quality
- From:
Progress in Modern Biomedicine
2025;25(9):1567-1575
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the analgesic effect of esketamine combined with ultrasound-guided sciatic nerve block on elderly patients with lower limb fractures and its impact on vital signs and sleep quality.Methods:92 elderly patients with lower limb fractures who were admitted to our hospital from August 2022 to August 2024 were divided into control group(injection of ropivacaine,n=46)and observation group(injection of esketamine combined with ropivacaine,n=46)by using random number table method.The Visual analogue pain score(VAS)in resting and active states,mean arterial pressure(MAP),heart rate(HR),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),cortisol(Cor),norepinephrine(NE)levels,pittsburgh sleep quality index(PSQI)between two groups were compared,and the occurrence of adverse reactions in both groups were observed.Results:Compared with the control group at 12 h and 24 h after surgery,the observation group had lower VAS scores in resting and active states(P＜0.05).Compared with the control group in tracheal extubation and 5 min after tracheal extubation,the observation group had lower HR and MAP(P＜0.05).Compared with the control group at 1 d and 3 d after surgery,the observation group had lower IL-6,Cor,NE,TNF-α and PSQI score(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Ultrasound-guided sciatic nerve block combined with esketamine on elderly patients with lower limb fractures,which has a good analgesic effect,can effectively reduce inflammatory stress response,maintain stable vital signs,improve sleep quality,and have good safety.
