Analysis of Factors Influencing Cognitive Dysfunction in Sepsis Survivors
10.11969/j.issn.1673-548X.2024.12.016
- VernacularTitle:脓毒症存活患者认知功能障碍的影响因素分析
- Author:
Qingsong MOU
1
;
Xiangning REN
1
;
Jinshuai LU
1
Author Information
1. 830000 乌鲁木齐,新疆维吾尔自治区人民医院急诊科、新疆急救中心
- Publication Type:Journal Article
- Keywords:
Sepsis;
Sepsis survivors;
Cognitive dysfunction;
Influencing factors
- From:
Journal of Medical Research
2024;53(12):88-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the current incidence of cognitive dysfunction in sepsis survivors and analyze the factors influ-encing cognitive function in these patients.Methods Patients treated for sepsis and discharged from the Emergency Center of the People's Hospital of the Xinjiang Uygur Autonomous Region between January 2022 and December 2023 were selected retrospectively.Based on the Changsha version of the Montreal cognitive assessment(MoCA),these patients were categorized into groups with and without cognitive dysfunction,to analyze the independent influencing factors of cognitive dysfunction in sepsis survivors.Results A total of 190 patients were included in the study,of which 106 patients were male(55.79％),and 91(47.9％)patients were identified with cognitive dys-function.Univariate analysis showed that there were significant differences in age,ICU length of stay,qSOFA score,SOFA score,A-PACHE Ⅱ score,WBC,lactate,BNP,D dimer and education level between the two groups(P＜0.05).Multivariate Logistic regression analysis revealed that age(OR=1.037,95％CI:1.004-1.072),length of intensive care unit(ICU)stay(OR=1.074,95％CI:1.001-1.149),blood ammonia levels(OR=1.023,95％CI:1.007-1.039),qSOFA score(OR=1.781,95％CI:1.113-2.851)and educational level(junior high school:OR=0.190,95％Cl:0.050-0.721;high school and vocational school:OR=0.105,95％CI:0.023-0.484;college and above:OR=0.083,95％CI:0.017-0.408)were independent factors influencing cogni-tive function in sepsis survivors.Conclusion Age,length of ICU stay,blood ammonia levels,and qSOFA score were identified as risk factors for cognitive dysfunction in sepsis survivors,whereas educational level served as a protective factor.
