Evaluation of Hemolytic Performance of Cellulose Hemostatic Products
10.13241/j.cnki.pmb.2025.09.005
- VernacularTitle:纤维素类止血材料的溶血性能评价
- Author:
Qing-qing HOU
1
;
Qin-lian JIAO
;
Chun-xia QIAO
;
Zi-ye WANG
;
Xiao-yan WANG
;
Wen-qian MA
;
Zeng-xiang LIU
;
Xiao-xia SUN
Author Information
1. 山东省医疗器械和药品包装检验研究院 山东 济南 250101
- Publication Type:Journal Article
- Keywords:
Cellulose;
Hemostasis;
Hemolysis;
pH;
Osmotic pressure
- From:
Progress in Modern Biomedicine
2025;25(9):1488-1495
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the differences in the evaluation of hemolysis performance of cellulose hemostatic materials using different detection methods and test media,and to explore a m ore reasonable testing plan for such products.Methods:Hemolysis tests were conducted on cellulose hemostatic materials using the absorbance measurement hemolysis method and hemoglobin concentration measurement hemolysis method in accordance with YY/T 1651.1-2019 standard.We compared the changes in hemolysis rate,pH value,and osmotic pressure under different experimental media.Results:Under the same experimental method,compared to SC,the hemolysis results using PBS as the extraction medium are smaller,and the changes in pH and osmotic pressure are closer to the normal range of human body changes.Conclusions:The changes in pH and osmotic pressure may be one of the reasons for the high hemolysis rate of cellulose hemostatic materials.Choosing PBS with buffering effect as the leaching medium may be more suitable for evaluating the hemolysis performance of cellulose hemostatic materials.
