Research Progress of CocrystalTechnology in Chiral Drug Resolution
10.3870/j.issn.1004-0781.2025.06.008
- VernacularTitle:共晶技术在手性药物拆分中的研究进展
- Author:
Yuhan GAO
1
;
Yue TAO
;
Hengming GOU
;
Baoxi ZHANG
;
Li ZHANG
;
Shiying YANG
;
Yang LYU
Author Information
1. 北京协和医学院·中国医学科学院药物研究所药物晶型研究中心,晶型药物研究北京市重点实验室,北京 100050
- Publication Type:Journal Article
- Keywords:
Cocrystal;
Chiral drugs;
Chiral resolution;
Enantiomer
- From:
Herald of Medicine
2025;44(6):886-893
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the demand for single enantiomer drugs has gradually increased,and the separation technology of chiral drugs has also been developed rapidly.In this article,we summarized the application and progress of cocrystal technology in chiral drug resolution,focusing on the existence forms of cocrystal former formations(single compound molecules,ions,and claths),the common preparation methods of cocrystal resolution,the physical and chemical factors affecting the resolution efficiency(co-formed chirality,solvent system,temperature)and the computer-aided prediction method of chiral cocrystal in the process of chiral drug resolution,to provide a reference for related research on chiral resolution using cocrystal technology.
