Diagnostic Value of IGF-1 and IL-17A in Children with Autism Spectrum Disorder
10.11969/j.issn.1673-548X.2024.12.024
- VernacularTitle:血清IGF-1和IL-17A在儿童孤独症谱系障碍中的诊断价值
- Author:
Chuanjie ZHANG
1
;
Jiamin SHEN
Author Information
1. 430015 武汉科技大学武汉儿童医院研究生培养基地
- Publication Type:Journal Article
- Keywords:
Autism spectrum disorder;
Insulin-like growth factor-1;
Interleukin-17A;
Diagnostic value
- From:
Journal of Medical Research
2024;53(12):136-139,121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of insulin-like growth factor-1(IGF-1)and interleukin-17 A(IL-17A)in children with autism spectrum disorder(ASD).Methods Eighty-six children aged 1 to 6 years with highly suspected ASD were recruited from the Department of Children Health Care,Wuhan Children's Hospital from January 2023 to December 2023.Diagnostic and Statistical Manual of Mental Disorders-5(DSM-5)was used to screen out ASD group and control group.,and the serum IGF-1 and IL-17A levels in the two groups were detected.Results Fifty-six ASD children were confirmed,accounting for 65％(56/86).Serum IGF-1 and IL-17A levels in ASD group were higher than those in control group,and the differences were statistically significant(P＜0.05).The serum IGF-1 and IL-17A levels with different clinical characteristics were compared,and there was no statistically significant difference in serum IGF-1 and IL-17A levels with age and gender in ASD group(P＞0.05).The children with severe ASD had significant higher serum IL-17A level than those with mild-to-moderate ASD(P＜0.05),while the difference in serum IGF-1 level between the two groups of severe and mild-to-moderate ASD was not statistically significant(P＞0.05).The Logistic regression analysis showed that overexpression of serum IGF-1 and IL-17 A was the influencing factor in the occurrence of ASD(OR＞1,P＜0.05).The receiver operating characteristic(ROC)curve analysis showed that the area under the curve(AUC)of serum IGF-1 and IL-17 A levels for diagnosing ASD alone and combination were 0.644,0.630 and 0.720.The combined detection had higher diag-nostic value.Conclusion Serum IGF-1 and IL-17A have the potential for early diagnosis of ASD,and the combined detection of the two levels is conducive to improving the diagnostic value of ASD.
