Research Progress on the Solid Form of Estradiol and Its Derivatives
10.3870/j.issn.1004-0781.2025.06.007
- VernacularTitle:雌二醇及其衍生物类药物固体形态的研究进展
- Author:
Juan XU
1
;
Xiaofeng CHEN
1
;
Lifeng NING
1
Author Information
1. 国家卫生健康委科学技术研究所,北京 100081
- Publication Type:Journal Article
- Keywords:
Estradiol;
Ethinylestradiol;
Estriol;
Solid form;
Polymorphism;
Co-crystal
- From:
Herald of Medicine
2025;44(6):881-885
- CountryChina
- Language:Chinese
-
Abstract:
Solid forms,such as polymorphs and co-crystals,can improve the physicochemical properties of drugs without changing their molecular structure,increasing their solubility,bioavailability,stability,and thus affecting their original pharmacodynamic activity.Estradiol and its derivatives ethinylestradiol and estriol,contain steroidal parent nucleus,which results in a very low water solubility.Researches showed that polymorphism and co-crystal studies could enhance the water solubility of estradiol and its derivatives.This paper reviews the research progress on the solid forms of estradiol and its derivatives in last decade.
