Enhanced Dissolution Behavior and Stability of Felodipine by Cocrystal Technology
10.3870/j.issn.1004-0781.2025.06.005
- VernacularTitle:共晶技术改善非洛地平稳定性及体外溶出度
- Author:
Yao ZOU
1
;
Xin MENG
1
;
Meiju LIU
1
;
Cheng XING
1
;
Ningbo GONG
1
;
Yang LYU
1
Author Information
1. 北京协和医学院·中国医学科学院药物研究所,晶型药物研究北京市重点实验室,北京 100050
- Publication Type:Journal Article
- Keywords:
Felodipine;
Cocrystal;
Crystal engineering;
Dissolution degree;
Dissolution rate
- From:
Herald of Medicine
2025;44(6):867-873
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop four novel cocrystals of felodipine aimed at improving its poor solubility.Methods Felodipine-caproamide,felodipine-2,4-dihydroxybenzoic acid,felodipine-2,5-dihydroxybenzoic acid,and felodipine-3,5-dihydroxybenzoic acid cocrystals were prepared using the slurry method.The cocrystals were characterized by powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC),thermogravimetric analysis(TGA),and Fourier-transform infrared spectroscopy(FT-IR).Stability tests and in vitro dissolution studies were conducted to assess their pharmaceutical properties.Results All four cocrystals demonstrated improved solubility and dissolution rates compared to pure felodipine.Notably,the felodipine-3,5-dihydroxybenzoic acid cocrystal showed superior stability and a marked increase in solubility.Conclusion Cocrystallization technology significantly enhanced the stability and dissolution profile of felodipine,underscoring its potential for pharmaceutical formulation development.
