Recombinant human endostatin-induced toxic epidermal necrolysis
10.3760/cma.j.cn114015-20210906-00972
- VernacularTitle:重组人血管内皮抑制素致中毒性表皮坏死松解症
- Author:
Jinfeng LI
1
;
Jia HOU
;
Xiaojin MIAO
;
Quan WANG
;
Fengjun LI
;
Yuan ZHANG
Author Information
1. 威海市立医院药剂科，威海 264299
- Publication Type:Journal Article
- Keywords:
Endostatins;
Epidermal necrolysis, toxic
- From:
Adverse Drug Reactions Journal
2022;24(3):166-168
- CountryChina
- Language:Chinese
-
Abstract:
A 59-year-old male patient received targeted drug recombinant human endostatin injection 15 mg intravenously once daily for 14 days for poorly differentiated adenocarcinoma of lung with brain metastasis. On the 17th day after drug withdrawal, erythema and pruritus appeared on the neck and chest, and then the erythema quickly spread to the whole body, with blisters and extensive epidermal exfoliation, accompanied by pruritus, pain, and mild fever. Toxic epidermal necrolysis caused by recombinant human endostatin was considered. High-dose of glucocorticoid and human immunoglobulin were given and 2 weeks later, the skin lesions healed basically.
