Causality Relationship Between Blood Metabolites and Hypertensive Heart Disease:A Two-sample Bidirectional Mendelian Randomization Study
10.11969/j.issn.1673-548X.2024.12.013
- VernacularTitle:血液代谢物与高血压性心脏病的因果关系:两样本双向孟德尔随机化研究
- Author:
Jiayong CHEN
1
;
Meiling TANG
;
Jianqi LU
Author Information
1. 530200 南宁,广西中医药大学
- Publication Type:Journal Article
- Keywords:
Metabolites;
Hypertensive heart disease;
Mendelian randomization;
Deoxycholic acid glucuronide;
Butyric/isobutyric
- From:
Journal of Medical Research
2024;53(12):67-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the causal relationship between blood metabolites and hypertensive heart disease(HHD)using two-sample bidirectional Mendelian randomization(MR)analysis.Methods HHD data were obtained from the Genome-wide Associ-ation Study(GWAS)database.A GW AS containing 1400 blood metabolites was used as an exposure factor,and single nucleotide poly-morphism(SNP)significantly associated with exposure factors were selected as instrumental variable(IV).The causal relationship be-tween 1400 blood metabolites and HHD was analyzed by'TwoSampleMR'and'gwasglue'packages of R software(V4.3.2).MR-Eggeer regression method,weighted median(WM)method,and inverse variance weighting(IVW)method and other methods were used.And a series of verification analyses such as heterogeneity,pleiotropic,and sensitivity and so on were performed.Finally,reverse MR a-nalysis was performed.Results IVW analysis of the causal relationship between 1400 blood metabolites and HHD showed that deoxychol-ic acid glucuronic(OR=0.847,95％CI:0.770-0.931)was a protective factor,and the risk of HHD decreased with the increase of this metabolite.Butyric/isobutyric(4∶0)(OR=1.316,95％CI:1.134-1.528)was a risk factor.With the increase of metabolites,the risk of HHD increased.Conclusion Butyric/isobutyric(4∶0)had effect of promoting HHD,and deoxycholic acid glucuronide had effect of inhibiting HHD.This may be a new idea and new basis for the future research and treatment of HHD.
