Insulin autoimmune syndrome induced by captopril
10.3760/cma.j.cn114015-20210330-00390
- VernacularTitle:卡托普利致胰岛素自身免疫综合征
- Author:
Xueting DU
1
;
Xiaoli ZHU
1
;
Lingna GAO
1
;
Hongshuang SUN
1
;
Hongfang MA
1
Author Information
1. 河北省衡水市人民医院药学部，衡水 053000
- Publication Type:Journal Article
- Keywords:
Captopril;
Autoimmune diseases;
Hypoglycemia
- From:
Adverse Drug Reactions Journal
2022;24(3):162-164
- CountryChina
- Language:Chinese
-
Abstract:
A 66-year-old female patient regularly received nifedipine sustained release tablets 20 mg twice daily and captopril 25 mg once daily by mouth for 2 years due to hypertension. Low blood glucose (3.0 mmol/L) appeared in recent 1 year, frequent hypoglycemic coma occurred in recent 4 months. Laboratory tests showed minimum fasting glucose 1.6 mmol/L, insulin 12 mU/L, C-peptide 1.78 nmol/L, and positive anti-insulin antibody. Insulin autoimmune syndrome was considered, which might be associated with captopril. Then captopril was stopped, nifedipine sustained-release tablets was continued, irbesartan hydrochlorothiazide was added, and prednisone 30 mg orally once daily was given at the same time. In addition, the patient was asked to adjust diet, including low carbohydrate and eating less and often. After stopping captopril for 3 days, her blood glucose was between 4.3 to 11.2 mmol/L, and hypoglycemia did not recur.
