Acute pancreatitis induced by tigecycline in a patient after renal transplantation
- VernacularTitle:替加环素致肾移植术后患者急性胰腺炎
- Author:
Donghua LIU
1
;
Xiaomin XING
1
;
Xue YANG
1
;
Yu LIANG
1
;
Jun ZHAO
1
;
Xuelian LIU
1
;
Jing YU
1
;
Yuefen LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Kidney transplantation; Pancreatitis; Tigecycline
- From: Adverse Drug Reactions Journal 2022;24(3):155-157
- CountryChina
- Language:Chinese
- Abstract: A 25-year-old male patient received intravenous infusion of tegacyclin 50 mg once per 12 hours from the 3rd day after renal transplantation because the bacterial culture of the donor kidney preservation solution showed carbapenem resistant Acinetobacter baumannii. On the 4th day after using tegacyclin, the patient developed epigastric pain, which was improved after gastric protection treatment. On the 8th day of medication, the patient developed persistent severe pain in his left lower abdomen. On the 9th day of medication, laboratory tests showed amylase 1 188 U/L and lipase 699 U/L. Pancreatic ultrasonic examination suggested acute edematous pancreatitis. Acute pancreatitis was diagnosed, which was considered to be related to tigecycline. Tigecycline was stopped. An IV infusion of octreotide acetate injection 0.6 mg dissolved in 0.9% sodium chloride injection 50 ml twice daily was given and diet was prohibited at the same time. Five days later, his symptoms of abdominal pain was improved significantly, pancreatic amylase decreased to 69 U/L, and lipase decreased to 646 U/L.
