Immune-related pneumonitis induced by camrelizumab
10.3760/cma.j.cn114015-20210223-00210
- VernacularTitle:卡瑞利珠单抗致免疫相关性肺炎
- Author:
Chunmei LI
1
;
Lijuan LIU
;
Yanzhen REN
;
Xuehai ZHOU
;
Yajun DAI
Author Information
1. 内蒙古自治区锡林郭勒盟中心医院药学部，锡林浩特 026000
- Publication Type:Journal Article
- Keywords:
Antineoplastic agents, immunological;
Pneumonia, interstitial;
Camrelizumab
- From:
Adverse Drug Reactions Journal
2021;23(12):666-668
- CountryChina
- Language:Chinese
-
Abstract:
A 49-year-old male patient received transcutaneous transcatheter arterial chemoembolization and an IV infusion of camrelizumab 200 mg (on day 1 and 14 days was a cycle) due to liver cancer with intrahepatic metastasis, liver cirrhosis, splenomegaly, and ascites. On day 12 after the third IV infusion of camrelizumab, the patient developed fever, cough, and chest tightness. On day 34 after the third IV infusion of camrelizumab, chest CT showed ground glass exudation shadow in bilateral lungs. Immune-related pneumonitis and infection caused by camrelizumab was considered. High-dose methylprednisolone was given to inhibit immune reaction and cefoperazone sodium and sulbactam sodium was given to resist infection, supplemented with symptomatic and supportive treatments such as oxygen inhalation and expectorant. Eighteen days later, the patient′s body temperature returned to normal, chest tightness disappeared, but he coughed occasionally. Chest CT showed that the ground glass exudation shadow of bilateral lungs was narrowed on the scope.
