Hyperprolactinemia caused by gabapentin
10.3760/cma.j.cn114015-20210218-00179
- VernacularTitle:加巴喷丁致高泌乳素血症
- Author:
Weibi CHEN
1
;
Miao LIU
;
Yan'gai WANG
;
Yan ZHANG
;
Yingying SU
Author Information
1. 首都医科大学宣武医院神经内科，北京 100053
- Publication Type:Journal Article
- Keywords:
Gabapentin;
Hyperprolactinemia;
Prolactin
- From:
Adverse Drug Reactions Journal
2021;23(12):670-672
- CountryChina
- Language:Chinese
-
Abstract:
A 15-year-old female patient with autoimmune encephalitis received methylprednisolone combined with plasma exchange and symptomatic treatments for convulsions, abnormal mental behavior, and involuntary facial and limb movements, including levetiracetam 0.5 g orally once per 12 hours, intramuscular injection of phenobarbital injection 0.1 g once per 6 hours, clonazepam 2 mg orally once per 8 hours, and gabapentin capsules 0.3 g orally once per 8 hours. Four days later, the dose of gabapentin was doubled; 7 days later, the patient had menstruation, but the amount of menstruation was very small; 10 days later, the patient developed lactation with serum prolactin 36.69 μg/L. Hyperprolactinemia was then diagnosed, which was considered to be related to gabapentin. Gabapentin was stopped and other drugs were continued. Six days later, the patient′s lactation disappeared and prolactin was 15.65 μg/L. In the following month, the patient′s menses returned to normal.
