Ameliorative effect of exercise on Alzheimer's disease and related mechanisms
10.3969/j.issn.1671-7856.2025.04.017
- VernacularTitle:运动对阿尔茨海默病的改善作用及机制
- Author:
Mingsheng XU
1
;
Kaihong SUN
Author Information
1. 扬州工业职业技术学院体育部,江苏扬州 225127
- Publication Type:Journal Article
- Keywords:
exercise;
Alzheimer's disease;
neuroinflammation;
neurogenesis;
blood-brain barrier
- From:
Chinese Journal of Comparative Medicine
2025;35(4):169-176
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of Alzheimer's disease(AD)is a key research focus in the field of life sciences.Exercise serves as an important intervention for ameliorating neurodegenerative diseases,and aerobic exercise,resistance training,and multimodal exercise combinations have been shown to significantly improve AD.Studies have shown that the pathogenesis of AD is closely associated with the regulatory effects of exercise in suppressing inflammatory responses,optimizing the activation of astrocytes and microglia,promoting hippocampal neurogenesis,and improving blood-brain barrier function.This article reviews the effects and mechanisms of different exercise method in improving AD and discusses future prospects,with the aim of providing a theoretical and experimental basis for the role of exercise in the prevention and treatment of AD.
