Research status on the regulation of the p38-MAPK signaling pathway in myocardial fibrosis of heart failure using traditional Chinese medicine
10.13699/j.cnki.1001-6821.2024.21.020
- VernacularTitle:中医药调控p38-MAPK信号通路在心力衰竭心肌纤维化中的研究现状
- Author:
Yi-bo WANG
1
;
Wan-min SHA
;
Ya-lu QIN
;
Hua WEI
;
Qi-yue MAO
;
Yan WANG
Author Information
1. 成都中医药大学临床医学院,四川成都 610075
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
p38-mitogen-activated protein kinase signal pathway;
heart failure;
myocardial fibrosis
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(21):3167-3170
- CountryChina
- Language:Chinese
-
Abstract:
The over expression of p38-mitogen-activated protein kinase(MAPK)is considered a crucial pathway leading to myocardial fibrosis(MF)in the development of heart failure(HF).Traditional Chinese medicine active ingredients,compounds,and patent medicines have significant advantages in preventing and treating collagen accumulation,inhibiting the process of myocardial fibrosis,improving the degree of heart failure,and enhancing cardiac function by regulating p38-MAPK.This article summarizes recent research on traditional Chinese medicine's treatment of HF MF through the p38-MAPK signaling pathway with the aim to provide new potential targets for preventing and treating HF MF.
