Research status of hydrogen sulfide in the prevention and treatment of gastrointestinal ischemia-reperfusion injury
10.13699/j.cnki.1001-6821.2024.21.021
- VernacularTitle:硫化氢防治胃肠道缺血再灌注损伤的研究现状
- Author:
Si-yu WU
1
;
Xu-tao SUN
1
;
Shuo CAO
1
;
Cai-yun MAO
1
;
Qi ZHOU
1
;
Yun-jia SONG
1
Author Information
1. 黑龙江中医药大学基础医学院,黑龙江哈尔滨 150000
- Publication Type:Journal Article
- Keywords:
hydrogen sulfide;
hydrogen sulfide donor;
gastrointestinal ischemia-reperfusion injury;
prevention and cure
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(21):3171-3175
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal ischemia reperfusion(I/R)injury is a major cause of high morbidity and mortality in patients with surgical trauma.At present,there are few studies on gastrointestinal I/R injury,so it is particularly important to find treatment methods for gastrointestinal I/R injury.As the third gas signaling molecule,H2S plays an important physiological and pathological role in the human gastrointestinal system.Recently,a variety of novel H2S donors such as ATB-344 and AP39 have shown therapeutic value for gastrointestinal I/R injury.Therefore,this article reviewed the treatment of gastrointestinal I/R injury by H2S donors and its mechanism of action,aiming to provide a new treatment method for gastrointestinal I/R injury,in order to provide a reference for clinical medication of gastrointestinal I/R injury.
