Acute phosphate nephropathy induced by sodium phosphates oral solution

VernacularTitle:磷酸钠盐口服溶液致急性磷酸盐肾病
Author: Huaji QI ¹ ; Kuifen MA ; Junhao LYU ; Qin ZHOU ; Wenhan PENG
Author Information

1. 杭州市余杭区第五人民医院药剂科，杭州　311100
Publication Type:Journal Article
Keywords: Phosphates; Acute kidney injury; Nephrocalcinosis
From: Adverse Drug Reactions Journal 2021;23(4):216-218
CountryChina
Language:Chinese
Abstract: A 55-year-old male patient with a history of hypertension and type 2 diabetes mellitus received sodium phosphates oral solution 45 ml diluted in 750 ml or more warm water in 2 divided doses for bowel cleansing on the night before and the morning of the day of colonoscopy. After the colonoscopy, the patient developed abdominal distension. Eighteen days after the colonoscopy, elevated serum creatinine (Scr) was found with a peak value of 175 μmol/L. Thirty-five days after the colonoscopy, Scr was 168 μmol/L and the glomerular filtration rate calculated by the plasma-creatinine-based equations Chronic Kidney Disease Epidemiology Collaboration was 38.54 ml/min. Renal puncture and pathological examination showed tubular epithelial cell injury with calcium phosphate deposits, and acute phosphate nephropathy was diagnosed. The patient was advised to drink more water and was given symptomatic treatments such as diuretic furosemide. Five months later, the Scr recovered to 105 μmol/L.