Priapism induced by paclitaxel for injection (albumin bound)

VernacularTitle:注射用紫杉醇（白蛋白结合型）致阴茎异常勃起
Author: Zhiyao HE ¹ ; Yuxian CHEN ; Yu YAN ; Zhou QIN ; Ting XU
Author Information

1. 四川大学华西医院临床药学部/肿瘤中心生物治疗科，成都　610041
Publication Type:Journal Article
Keywords: Albumin-bound paclitaxel; Priapism
From: Adverse Drug Reactions Journal 2021;23(4):210-211
CountryChina
Language:Chinese
Abstract: A 66-year-old male urothelial carcinoma patient with liver and lymph node metastasis received an IV infusion of paclitaxel for injection (albumin bound) 400 mg on day 1 and tegafur, gimeracil and oteracil potassium capsules 50 mg orally twice daily on day 1 to day 14, the interval was 1 week, and each cycle was 21 days. A total of 9 cycles of chemotherapy were performed. The patient complained of priapism occurring about 15 hours (about 1: 00 of the next morning) after intravenous infusion of paclitaxel (albumin bound) in the cycles 1-5 and 7-9, which could disappear about 2 hours later. No special treatment was given. After that, paclitaxel for injection (albumin bound) was not used, and the patient did not have the above symptoms again after changing to immunotherapy as disease progresses. It was considered that the patient′s priapism might be related to paclitaxel for injection (albumin bound).