Clinical characteristics,molecular mechanisms,and progress in diagnosis and treatment of mucinous gastric adenocarcinoma
10.7659/j.issn.1005-6947.250049
- VernacularTitle:胃黏液腺癌的临床特征、分子机制及诊疗进展
- Author:
Yuchen LUO
1
;
Qiulin HUANG
1
Author Information
1. 南华大学附属第一医院胃肠外科,湖南衡阳 421000
- Publication Type:Journal Article
- Keywords:
Stomach Neoplasms;
Adenocarcinoma,Mucinous;
Prognosis;
Review
- From:
Chinese Journal of General Surgery
2025;34(4):787-795
- CountryChina
- Language:Chinese
-
Abstract:
Mucinous gastric adenocarcinoma(MGC)is a distinct but under-researched subtype of gastric cancer,accounting for approximately 2.2％to 6.8％of all cases.It is characterized by the presence of ≥50％extracellular mucin within the tumor tissue.Although recognized as an independent subtype by international classification standards,significant controversies persist regarding the definition criteria,clinical prognosis,and treatment strategies of MGC.This article systematically reviews the epidemiological features,histological evolution,molecular mechanisms,and imaging characteristics of MGC,with a particular focus on the key issues related to definitional discrepancies,prognostic contradictions,and therapeutic challenges.Addressing these issues may provide references for optimizing clinical diagnosis and treatment,promote the development of individualized therapeutic strategies for MGC,and offer theoretical support for reducing global disparities in gastric cancer management.
