Research progress on the mechanism of acute leukemia mediated by ferroptosis
10.3969/j.issn.1671-7856.2025.04.015
- VernacularTitle:铁死亡介导急性白血病的机制研究进展
- Author:
Dacheng ZHU
1
;
Yan LIU
1
;
Jiaxu WEI
1
Author Information
1. 江西中医药大学,南昌 330004
- Publication Type:Journal Article
- Keywords:
ferroptosis;
acute leukemia;
ROS;
LPO
- From:
Chinese Journal of Comparative Medicine
2025;35(4):150-158
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is closely related to iron metabolism,lipid metabolism,and amino acid metabolism,which contribute to the production of reactive oxygen species,mitochondrial damage,and cell death.Ferroptosis has recently been recognized as a key regulatory mechanism during tumor development,including in acute leukemia.This review considers the inhibitory effects of drugs on the occurrence and development of acute leukemia,by regulating key proteins or factors involved in the above three metabolic pathways of ferroptosis and by interfering with the production of lipid peroxides.We also point out the deficiencies in current research and describe the role of ferroptosis in acute leukemia.The application of these findings in clinical trials will provide new ideas for future research and the treatment of leukemia.
