Hyponatremia encephalopathy caused by compound polyethylene glycol electrolytes powder (Ⅲ)
10.3760/cma.j.cn114015-20200907-00938
- VernacularTitle:复方聚乙二醇电解质散（Ⅲ）致低钠性脑病
- Author:
Yuanyuan MA
1
;
Zhibin CHEN
1
;
Tan WANG
1
Author Information
1. 海南医学院第一附属医院神经内科，海口 570102
- Publication Type:Journal Article
- Keywords:
Polyethylene glycols;
Hyponatremia;
Mental disorders;
Brain edema
- From:
Adverse Drug Reactions Journal
2021;23(3):163-164
- CountryChina
- Language:Chinese
-
Abstract:
A 47-year-old female patient received compound polyethylene glycol electrolytes powder (III) 4 bags (73.59 g/bag) dissolved in 4 L warm water in 16 divided doses to prepare for colonoscopy the next day. The patient took medicated warm water 2 L within 2 hours. She had loose stool and watery stool for more than 10 times within 1 hour after medication. The patient did not continue to take drugs because of the severe diarrhea. Fourteen hours after medication, the patient developed apathy, no response to voice stimuli, and involuntary movement of both upper limbs. Sixteen hours after medication, the patient developed unconsciousness and tetanic convulsion of limbs. Laboratory tests showed that serum sodium was 120 mmol/L and plasma osmolality was 258.22 mOsm. She was diagnosed with hyponatremia encephalopathy. Except polyethylene glycol electrolytes powder (III), the patient did not take any other drug. It was considered that hyponatremia encephalopathy was related to polyethylene glycol electrolytes powder (III). Symptomatic treatments such as sodium supplement and dehydration were given immediately. After 1 hour of treatment, the patient′s consciousness recovered; 8 hours later, her serum sodium was 142 mmol/L.
