Delayed skin rash and pigmentation caused by combination use of cytarabine and idarubicin
10.3760/cma.j.cn114015-20200420-00434
- VernacularTitle:联合应用阿糖胞苷和伊达比星致迟发性皮疹和皮肤色素沉着
- Author:
Huanli YIN
1
;
Yuan HUANG
1
;
Zhaoyang CHEN
1
;
Ting XU
1
Author Information
1. 四川大学华西医院临床药学部，成都 610041
- Publication Type:Journal Article
- Keywords:
Cytarabine;
Idarubicin;
Drug eruptions;
Skin pigmentation
- From:
Adverse Drug Reactions Journal
2021;23(2):106-107
- CountryChina
- Language:Chinese
-
Abstract:
A 37-year-old male patient with acute myelomonocytic leukemia received cytarabine combined with idarubicin for 4 times. The patient did not develop rash or skin damage during the chemotherapy except for myelosuppression and vomiting. The patient developed slight itching on the extremities on the 4th day after the 5th intravenous infusion of idarubicin (20 mg once daily, on day 1) and cytarabine (1 900 mg once per 12 hours, on day 1 to 4), and no special treatment was given. On the 2nd day after finishing the chemotherapy, the patient developed obvious dark brown pigmentation on both cheeks and red papules on his back and bilateral waist, which was considered to be related to combination use of cytarabine and idarubicin. Chlorphenamine maleate 4 mg orally once per 12 hours, and IV infusions of 20% vitamin C injection 5 ml+0.9% sodium chloride injection 100 ml+10% calcium gluconate injection 10 ml once daily were given. Seven days later, the red papules on his back and waist disappeared; 24 days later, his facial pigmentation disappeared basically.
