Propofol infusion syndrome caused by long-term continuous intravenous pumping of propofol
10.3760/cma.j.cn114015-20200305-00217
- VernacularTitle:长期持续静脉泵入丙泊酚致丙泊酚输注综合征
- Author:
Bo LIU
1
;
Huaiwu HE
;
Yun LONG
Author Information
1. 济宁医学院附属医院重症医学科，济宁 272000
- Publication Type:Journal Article
- Keywords:
Propofol;
Propofol infusion syndrome;
Rhabdomyolysis;
Acute kidney injury;
Sepsis
- From:
Adverse Drug Reactions Journal
2021;23(2):104-105
- CountryChina
- Language:Chinese
-
Abstract:
A 48-year-old male patient with myocardial infarction received continuous intravenous pumping of propofol 1-2 mg/(kg· h) for 21 days due to delirium after cardiopulmonary resuscitation. On the 19th day after intravenous pumping of propofol, the patient developed high fever (the highest body temperature was 40.0 ℃), decreased blood pressure (the lowest level was 90/60 mmHg), decreased urine volume (10 ml/h), and dark urine. The laboratory tests showed white blood cell count (WBC) 17.3×10 9/L, hemoglobin (Hb) 88 g/L, procalcitonin (PCT) 12.76 μg/L, cardiac troponin I (cTnI) 0.342 μg/L, serum creatinine (Scr) 239 μmol/L, creatine kinase (CK) 34 667 U/L, myoglobin (myo) 58 284 μg/L, lactic acid 2 mmol/L, and fungal (1-3)-β-D-glucan 457.9 ng/L. Candida albicans was identified from blood culture. The patient was diagnosed with propofol infusion syndrome and sepsis. Propofol was stopped immediately and replaced by continuous intravenous pumping of midazolam injection (5 mg/h). At the same time, treatments such as anti-infection and continuous bedside hemofiltration were given. After 3 days of treatments, the patient′s temperature dropped to within the normal range. After 7 days of treatments, laboratory tests showed WBC 5.6×10 9/L, Hb 95 g/L, PCT 0.12 μg/L, cTnI 0.023 μg/L, CK 43 U/L, myo 151 μg/L, Scr 78 μmol/L, and fungal (1-3)-β-D-glucan 88.9 ng/L. His urine volume was 90-100 ml/h.
